Transcript – Comparative Models of NSAID-Induced Intestinal Inflammation

We like to compare the models instead induced intestinal inflammation. This is an important area given the prevalence of diseases in both people and animals. The model we looked at specifically was the effects of nonsteroidal antiinflammatory drugs on the gastrointestinal tract in approximately 30 percent of adults take insets in the United States each day to manage a host of painful and inflammatory conditions. The same is true for veterinary medicine, although the exact numbers are less well documented. Despite the frequency of use of these kinds of medications, they do have several side effects. Those on the GI tract being among the worst. The effects of intense on the GI tract remain underdiagnosed, but still commonly cause issues. Approximately sixteen thousand Americans die each year because of the effects of enzymes on the GI tract. Another 100000 or so are hospitalized. Importantly, there are no effective management or prevention strategies for the effects of insights on the GI tract. And the reasons for this are unclear. The reasons for this are unclear. But there are two important issues. One is that we still poorly understand the pathophysiology of the effects of an says on the GI tract.

And second is that there’s a lack of a good animal model to recapitulate this disease. Mouse and other small rodent models are most commonly used by these species, are known to have extreme sensitivity to the effects of insects and therefore the results obtained in those species do not translate to the human to human medicine very well. Therefore, we set out to compare to large animal models with the mouse models. We looked at porcine model and equine model and of course the mouse model of intended neuropathy. And what we found is that mice get extreme injury to the GI tract because of insects. Pigs are resistant to the effects of insects and horses are in the middle where they have some injury to both the upper and lower GI tract. Interestingly, all three species develop severe gastric ulcers in response to NSAIDs, but only the mouse and horse develop lower GI injury. And it’s a lower GI effects of insects that are so that are associated with the morbidity and mortality with falling use.

So we propose that the horse may be a more effective model for insect induced intestinal inflammation as compared with the mouse.